Everything You Need to Know About PDRN and Why Celebs Like Kim Kardashian Swear by It!

PDRN is the skincare ingredient everyone’s talking about—but did you know it comes from fish DNA? Hollywood A-listers like Jennifer Aniston and Kim Kardashian swear by its skin-rejuvenating benefits. But, what makes it so powerful?

Here’s everything you need to know about how this powerhouse ingredient works, why it’s gaining so much attention in the beauty world, and the best treatments and products to incorporate into your skincare routine.

What Is PDRN?

@jasminnlily_

Salmon DNA for glowy skin 🐟✨ @anua_global ad PDRN has become one of my essential skincare ingredients and this serum has a high concentration of it! 🤍 #skincare #pdrn #koreanskincare #anuapdrn #anuapdrnserum #koreanskincare101 #skincareroutine #anua

♬ original sound – Jasmin

So, what exactly do these four letters stand for and why is everyone talking about it? Short for Polydeoxyribonucleotide, PDRN is a DNA-derived compound that’s quickly gaining popularity in the skincare world.

Extracted from the sperm of salmon or trout, this natural ingredient is renowned for its skin regeneration and repair properties. Yes, fish DNA—sounds surprising, right?

But it’s no secret among Hollywood A-listers. Celebrities like Jennifer Aniston, Kim Kardashian, and Denise Richards have publicly discussed trying salmon sperm facials, fueling even more curiosity about this game-changing treatment.

Kim Kardashian even spoke about it on her family’s reality TV show, The Kardashians, saying, “I got a salmon sperm facial with salmon sperm injected into my face,” while talking to her mum and manager, Kris Jenner.

Despite its unexpected source, PDRN has become a go-to skincare ingredient for its powerful regenerative effects.

The Benefits of PDRN for Your Skin

Despite its unique origin, this skin-rejuvenating ingredient has become a powerhouse in K-beauty, highly valued for its ability to regenerate and repair the skin. Originally used in medical treatments for wound healing, it has now found its place in aesthetic skincare, particularly in professional treatments.

This powerhouse compound is known for its ability to:

• Stimulates collagen production to reduce fine lines and wrinkles
• Improves skin elasticity, making it firmer and more resilient
• Accelerate skin healing, ideal for acne scars and damaged skin
• Deeply hydrates, preventing dryness and dullness

Thanks to these benefits, this skin-nourishing compound is a key component in aesthetic treatments such as skin boosters and injections, offering long-term skin rejuvenation.

It enhances overall skin texture, making it a sought-after solution for those looking for intensive care beyond topical products.

Top PDRN Skincare Treatments

PDRN is incorporated into a variety of aesthetic procedures to rejuvenate and enhance skin health:

PDRN Facial

An invasive procedure where tiny injections of this skin-rejuvenating compound are delivered directly into the dermis to kickstart skin regeneration and repair. This targeted treatment addresses concerns like acne scars, fine lines, and hyperpigmentation, leaving skin looking revitalised and youthful.

Common treatment areas include:

• Face: To target fine lines, wrinkles, and enhance overall skin rejuvenation.
• Neck and Décolleté: To improve skin elasticity and reduce signs of sagging.
• Hands: To restore lost volume and smoothen skin texture.
• Other Areas: Such as acne scars, uneven pigmentation, or skin damage on different parts of the body.

These facials treatments are customisable, allowing you to focus on the areas that require the most attention, ensuring a tailored approach for optimal results.

Skin Boosters

These treatments, often using hyaluronic acid or similar hydrating ingredients, focus on deeply moisturising and improving skin elasticity.

While they can also help reduce fine lines, their primary aim is to enhance overall skin quality by boosting hydration and radiance, giving the skin a plumper, more youthful appearance.

Serums and Topical Treatments

For those who prefer a non-invasive option, PDRN can now be found in serums and creams, offering a gentler way to experience its regenerative benefits. These products provide a non-invasive option for those looking to hydrate, rejuvenate, and restore the skin’s youthful appearance.

How Much Do PDRN Treatments and Skincare Cost in Singapore?

Due to its unique harvesting technique, PDRN treatments can be expensive. For aesthetic treatments, the cost can range from S$500 to S$1,500 per session, depending on the type of procedure, the clinic, and the area being treated.

However, in products like serums and creams, since PDRN is infused with other ingredients, the costs are typically lower, ranging from S$100 to S$300, making it a more accessible option for daily skincare routines.

Top 5 Clinics to Visit for PDRN Treatments in Singapore

PDRN skin booster injections are one of the most popular beauty treatments in Korea, and now they’re available in Singapore too. If you’re looking to give your skin a professional boost, check out these top spots to experience this rejuvenating treatment.

Bio Aesthetic Laser Clinic 4.9/5 stars on Google!

Bio Aesthetic Laser Clinic offers salmon DNA extract treatment, an all-round solution ideal for addressing acne scars, skin recovery, and overall skin rejuvenation. Known for its anti-inflammatory properties, it’s also gentle enough for sensitive skin.

This treatment helps promote skin regeneration and repair, making it a popular choice for those looking to restore their skin’s health and appearance.

Reviews:

I’ve been doing facial treatment frequently at this clinic with therapist Han Jing for almost two years and my face has improved so much with each session. – Cindy Sao, Google

I’ve been coming to the clinic for over 1 year and so far it has been great, seeing improvement on my skin. – Dora, Google

What We Like:

1. Three different types of PDRN treatments to choose from
2. Provides customised consultations and solutions for PRDN

What to Consider:

1. May require several treatments for specific areas
2. Can be expensive, especially if multiple sessions are required

Illumia Medical Orchard – Aesthetic Clinic 4.7/5 stars on Google!

Illumia Medical Orchard offers PDRN Skin Booster treatments, known for their safety and effectiveness when administered by qualified professionals. The treatment uses biocompatible ingredients, ensuring it’s well-tolerated by all skin types.

Perfect for enhancing skin regeneration and rejuvenation, it targets various skin concerns, providing long-lasting results with minimal risk, making it a trusted choice for skincare.

Reviews:

I have been doing facials and laser treatment with Illumia for almost 2 years now. Happy to share that my skin has improved significantly! Shixuan Sun, Google

An extremely enjoyable experience. Staffs are very prompt and polite. Plus, doctors are knowledgeable about the best market practises. – Nic L, Google

What We Like:

1. You’ll never feel pressured to sign any treatment packages
2. Reviewers claimed that the staff are very professional and friendly

What to Consider:

1. Have an open discussion about side effects, though they’re rare
2. The PDRN Eye Booster can be expensive for some

Radium Medical Aesthetics 4.7/5 stars on Google!

Radium Medical Aesthetics offers PDRN Skin Therapy, a minimally invasive treatment that uses micro-needles to deliver PDRN directly beneath the skin for skin regeneration and rejuvenation.

The procedure begins with a topical numbing cream to ensure comfort. With treatment taking only about 15 minutes, Radium is known for its expertise in delivering safe, effective results for a refreshed complexion.

Reviews:

I trust Dr Siew and the team at Radium! The results show, my skin looks amazing now! Katherinne Kuan, Google

I had a wonderful experience with Dr Siew. He is very knowledgeable, experienced and of cos fast and skilful. – Wendy Chua, Google

What We Like:

1. Provides consultation before agreeing to any treatment procedures
2. Reviewers claimed that Dr Siew and the team at Radium are very knowledgeable

What to Consider:

1. Treatment price depends on your skin condition and sessions needed
2. Waiting period can be longer than expected

The Clifford Clinic 4.8/5 stars on Google!

At The Clifford Clinic, PDRN treatments are tailored for various skin concerns. PDRN HB (Hydro Boost) strengthens regeneration, boosts hydration, and repairs the skin.

PDRN I targets wrinkles around the eyes, improving elasticity and reducing crow’s feet, while the PDRN S treats acne scars, particularly sunken ones, by increasing volume to remodel the skin, giving a smoother appearance.

Reviews:

Thank you Dr Law and the whole Team for making this experience truly reassuring and comforting. L.P, Google

I recently visited The Clifford Clinic for acne treatment and had an amazing experience! – Herman Salleh, Google

What We Like:

1. Experienced, qualified medical professionals
2. Clean, hygienic, and comfortable treatment environment

What to Consider:

1. Results may vary depending on individual and other various factors
2. Ask about any potential side effects or risks

Mirage Aesthetic 4.8/5 stars on Google!

With zero downtime and advanced technology, Mirage Aesthetics offers the PDRN Skin Regeneration Treatment using Dermoelectroporation (D.E.P) to effectively rejuvenate your skin.

This non-invasive treatment delivers PDRN deep into the skin’s hypodermis, boosting hydration, reducing wrinkles, and improving skin texture. It’s a safe, FDA-approved treatment for those looking for youthful, glowing skin without needles or side effects.

Reviews:

Thank you Dr Law and the whole Team for making this experience truly reassuring and comforting. L.P, Google

I recently visited The Clifford Clinic for acne treatment and had an amazing experience! – Herman Salleh, Google

What We Like:

1. Great for dull and saggy skin, as well as to combat uneven skin tone
2. Clean, hygienic, and comfortable treatment environment

What to Consider:

1. Duration of treatment takes about 90 minutes, including consultation
2. May be pricey for some, so check on pricing and payment options

Everything You Need to Know About PDRN Serums

@kbeautymom

Replying to @Nvh Anua PDRN or Medicube PDRN? 🤔👀 ✨Both have PDRN + Niacinamide + Hydrolyzed Collagen + Tumeric Extract 💖Medicube also contains 5 types of Peptides for additional anti-aging benefits ✨Anua PDRN has Hyaluronic Acid for extra hydration #olivekollection #pdrn #pdrnserum #pdrnpinkserum #antiaging #finelines #wrinkleprevention #wrinklesbegone #anuapdrn #medicubepdrn

♬ original sound – Christina

For those hesitant about needles, PDRN serums provide an easy, non-invasive way to experience its skin-repairing benefits. They’re a great option for testing how your skin responds to the ingredient before considering more advanced treatments like skin boosters or injections.

Why PDRN serums stand out:

• Boosts Hydration: Replenishes moisture, leaving dry or dehydrated skin soft and plump
• Gentle on All Skin Types: Biocompatible and extracted from salmon DNA, making it well-tolerated by all skin types
• Easy to Layer: Work seamlessly with other skincare products like moisturisers, sunscreens, and serums.

While serums offer a more gradual effect compared to in-clinic treatments, consistent use can lead to noticeable improvements in skin texture, fine lines, and overall radiance. Plus, they’re a budget-friendly way to incorporate PDRN into your routine without committing to professional procedures.

Patch Test First

If you’re using PDRN for the first time, always do a patch test on a small area of your skin. This helps ensure you won’t have an adverse reaction, especially if you have sensitive skin.

Best PDRN Serums in Singapore

As this skin-rejuvenating ingredient gains popularity, it’s now making its way into everyday skincare, bringing its powerful benefits to more people. Not keen on injections? Here are some of the best skin-repairing serums in Singapore:

Medicube PDRN Pink Peptide Glow Serum

Designed to tackle uneven skin tone and boost elasticity, this powerful serum helps you achieve a radiant, healthy-looking complexion. With visible results in just two weeks, it keeps your skin glowing and hydrated for hours.

The lightweight, fast-absorbing formula melts right in, leaving your skin soft, plump, and dewy. If you’re after that fresh, luminous look, this serum might just be your new skincare must-have!

Medicube PDRN Pink Peptide Glow Serum retails for S$35, now S$24 after discount on Medicube. 

Clair® Skin Solutions PDRN Regenerative Serum Concentrate

This serum boosts collagen production to repair the skin, reduce acne scars, and evens out pigmentation. Probiotic Lactobacillus provides antioxidants and firming benefits, while arbutin brightens and smooths the skin for a baby-soft finish.

Suitable for all skin types, it is free from parabens, alcohol, and artificial colourants.

Clair® Skin Solutions PDRN Regenerative Serum Concentrate retails for S$131 on Tangs. 

ANUA PDRN Hyaluronic Acid Capsule 100 Serum

Infused with a potent blend of salmon DNA extract, hyaluronic acid, and collagen, this formula delivers a radiant glow in just three seconds while instantly plumping the skin.

These powerhouse ingredients work in synergy to provide deep hydration and revitalisation from within. With low molecular weight collagen, it fortifies the skin barrier and boosts elasticity for a firmer, smoother complexion.

ANUA PDRN Hyaluronic Acid Capsule 100 Serum retails S$32 on Stylevana. 

Cerm Beauty HA SHOT & PDRN Serum

Harnessing the power of microneedle technology, this serum delivers salmon DNA extract, hyaluronic acid, and adenosine deep into the skin for optimal rejuvenation.

The regenerative extract promotes renewal, hyaluronic acid provides intense hydration, and adenosine helps combat signs of ageing—working together to restore, plump, and smooth your complexion.

Cerm Beauty HA SHOT & PDRN Serum retails for S$65 on Cerm Beauty. 

Real Barrier PDRN Glow Repair Serum

To restore and maintain skin elasticity, Realbarrier’s serum contains exosomes derived from probiotics, which are naturally present in healthy skin in the 20s, revitalising your skin.

Its unique hyaluronic acid sphere encases seaweed-derived repair complex for deep hydration, while vitamin B12 enhances moisture and vitality. The exclusive Triple Ceramide Complex strengthens the skin barrier, promoting repair and resilience for a healthier, more balanced complexion.

Real Barrier PDRN Glow Repair Serum retails for S$44.88 on Olive Young. 

SKINFOOD Salmon PDRN Eyelash Serum

If you think salmon-infused serums are only for the face, think again! This eyelash serum is packed with salmon DNA and peptides to strengthen and nourish your lashes.

Its unique formula, enriched with patented ingredients and plant-based peptides, supports lash growth while biotin boosts hair root strength. Plus, panthenol in here adds softness, shine, and vitality, for fuller-looking lashes over time.

SKINFOOD Salmon PDRN Eyelash Serum retails for S$27.20 on Olive Young. 

Centellian24 360° Shot PDRN Active Serum

Great to use on six key areas affected by ageing—forehead, eye area, cheeks, around the mouth, nasolabial folds, and under the chin—this formula helps lift and firm for a sculpted, 3D effect. Perfect for sagging skin, it provides targeted support to restore a firmer, more youthful look.

Centellian24 360° Shot PDRN Active Serum retails for S$35 on Centellian24 and S$46.63 on Best Korean Skincare.